Prince Frederik of Luxembourg dies at 22 from Polymerase Gamma (PolG) mitochondrial disease |
Prince Frederik of Luxembourg, son of Prince Robert of Luxembourg and Princess Julie of Nassau, has died at the age of 22 due to a rare genetic disorder known as PolG mitochondrial disease. His death occurred on March 1 in Paris, according to a statement issued by his family.
The announcement was made via the website of the POLG Foundation, an organization founded by Frederik to support research into the disease. According to the statement, Frederik was diagnosed at age 14 after symptoms became more pronounced.
Prince Robert stated that Frederik called family members to his room on February 28 to speak with them before his death. The statement also referenced the foundation’s work and its connection to Frederik’s diagnosis and ongoing health condition.
What is PolG mitochondrial disease?
PolG mitochondrial disease is caused by mutations in the POLG gene. It is a disorder that affects the function of mitochondria — the structures responsible for producing energy in cells. The condition can impact multiple organs, including the brain, nerves, muscles, and liver, and may also impair vision.
There is currently no cure for the disease. Treatment is typically limited to managing symptoms and improving the patient’s quality of life, according to the United Mitochondrial Disease Foundation.
In a previous video published by the POLG Foundation, Frederik discussed the effects of the disease on his daily life and mobility. He described how the condition gradually limited his physical capabilities over time.
Prince Frederik was a member of Luxembourg’s Grand Ducal family, part of the world’s only remaining sovereign grand duchy. He was not in line for the throne but was part of the extended royal family. His father, Prince Robert, is a first cousin of Luxembourg’s reigning monarch, Grand Duke Henri.
